Tolerability of Iron Preparations

Side-effects of oral iron therapy are a common problem.2 GI disturbances such as nausea, heartburn, pain, constipation and diarrhoea are the most commonly reported side-effects.2 These intolerances may impact patient compliance and possibly lead patients to withdraw from treatment.2

Controlled release dosage forms such as ferrograd® control the rate at which the drug is released to provide a sustained drug release over an extended period.

Controlled Release Oral Drug Delivery

Oral iron therapy in appropriate doses, for a sufficient duration, is an effective first-line strategy for most patients.1

Sustained release oral drug delivery systems may provide
important advantages over conventional oral dosage forms:

  • Reduced dosing frequency contributing to improved patient compliance3,4
  • Less fluctuation in plasma drug concentrations, thereby improving therapy and decreasing side-effects4
  • Sustained plasma drug concentration within the therapeutic range, thereby improving efficacy and decreasing side-effects.4

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1. Pasricha SS et al. Diagnosis and management or iron deficiency anaemia: a clinical update Med J Aust 2010; 193: 525-532.

2. Santiago P. Ferrous versus Ferric Oral Iron Formulations for the Treatment of Iron Deficiency: A Clinical Overview. The Scientific World Journal Volume 2012; 1-5.

3. Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001; 23:1296-1310.
4. Benson, HAE, Prankerd RJ. Optimisation of Drug Delivery. The Australian Journal of Hospital Pharmacy; Vol 27, No.5. 1997;381-389.


ferrograd® (dried ferrous sulfate 325 milligrams, equivalent to 105 milligrams elemental iron) ferrograd® C (dried ferrous sulfate 325 milligrams, equivalent to 105 milligrams elemental iron and vitamin C 500 milligrams). Pharmacy Only Medicine.  Indications: For the prevention and treatment of tiredness and fatigue associated with iron deficiency. Contraindications: Hemochromatosis and hemosiderosis, intestinal diverticula or obstruction, repeated blood transfusions and concomitant parenteral Fe. Precautions: Establish nature and cause of anaemia. Children. Adverse Effects: GI upset, black stools. Dosage & Administration: One tablet daily as directed by physician. Tablets should be swallowed whole. Iron supplements should not be taken for more than 12 months without consulting a healthcare professional. ferrograd® is a fully funded medicine. ferrograd® C is an unfunded medicine. Your patient will need to pay for this medicine. ferrograd® is a registered trademark of BGP Products S.a.r.l, Mylan NZ Ltd., Auckland.  TAPS DA1927DA-194.